Exploitation and utilization of mineral resources have played a vital role in China's rapid economic developments. Although the history of mineral processing is quite long, technologies in this field have varied with the changes of market demands. This is particularly the case for minerals whose high-grade deposits are depleting. The aim of this review is to present our recent efforts on developing new routes for the utilization of low-grade minerals, such as iron ores and brine-containing lithium. The emphasis on the two minerals lies in the fact that iron plays a vital role in modern-day civilization and lithium is a key component in electric vehicles for transportation. Furthermore, the utilization of magnesium chloride reserves, one of the largest wastes in western China, as raw materials for fabrication of functional materials is also included in this review.