화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.84, 280-289, April, 2020
DOI10.1016/j.jiec.2020.01.009  Export Citation
Experimental and theoretical studies of drug-polymer interactions to control the drug distributions in dissolving microneedles
Jing Ling Liu1, 2, Yun Hao Feng1, 2, Xiao Peng Zhang1, 2, Dan Dan Zhu1, 2, Li Qin Zhang1, 2, and Xin Dong Guo1, 2, †
  • 1Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, PR China
  • 2Key Lab of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology), Ministry of Education, Beijing, 100029, PR China
E-mail:
Dissolving microneedles (DMNs) have attracted extensive attention for transdermal drug delivery in recent years. Generally, the skin elasticity impedes DMNs to fully insert into skin thus optimized fabrication methods are needed to improve delivery efficiency. Here, we investigated the formulations of DMNs as the main influencing factors during the microneedle preparation process. Through the selection of the matrix materials and the optimization of the ratio and formulae, the DMNs can meet the requirements of convenient and effective drug delivery. For DMNs prepared with polyvinyl alcohol (PVA) as matrix material, the 25 wt% concentration of PVA was beneficial to prepare MNs, which MNs was able to focus drug on the part of MN tips. However, for DMNs fabricated with hyaluronic acid (HA), the increasing material concentration had a weaker ability to concentrate drug in MNs and increased the difficulty of preparing MNs. The computer simulation analysis was consistent with the results of the experiment, indicating the feasibility of modelling to investigate the preparation technology of DMNs that offer appropriate, convenient and highly efficient drug delivery.
Keywords:Dissolving microneedles;Drug delivery;Drug distribution;Computer stimulations
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