Development of Blood Compatible Composite Using MPC Copolymer and Polyolefin for Non-PVC Blood Bag Application

Seung Kyun Yoon; Dong June Chung

Macromolecular Research, Vol.28, No.4, 319-326, April, 2020

DOI10.1007/s13233-020-8047-7 Export Citation

Development of Blood Compatible Composite Using MPC Copolymer and Polyolefin for Non-PVC Blood Bag Application

Seung Kyun Yoon, and Dong June Chung^†

School of Chemical Engineering, Sungkyunkwan University, 2066 Seobu-Ro, Jangan-Gu, Suwon, Gyeonggi 16419, Korea

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Polyolefin is a good candidate for a blood bag material alternative to the poly (vinyl chloride) (PVC) blood bag that contains di-2-ethylhexyl phthalate (DEHP). However, polyolefin readily adsorbs some plasma proteins and platelets. To prevent these undesired adsorption, 2-methacryloyloxyethyl phosphorylcholine (MPC) ? hydroxyethyl methacrylate (HEMA) ? lauryl methacrylate (LMA) copolymers with varying monomer ratios were synthesized and used as blended material for additives to reduce platelet adsorption. Platelet adsorptive properties were reduced by blending MPC copolymers with polyolefin and confirmed by the platelet adhesion test and the activated partial thromboplastin time (APTT) test.

Keywords:MPC;HEMA;LMA;polyolefin;platelet adhesion test;APTT test;blood bag application

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Khang G, Lee JH, Lee HB, Polym. Sci. Technol., 7(3), 312 (1996)
Lee JH, Kim KO, Ju YM, Biomed. Mater. Res., 48, 328 (1999)
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Park KH, Chung DJ, Biomater. Res., 19, 2 (2015)
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Lewis AL, Hughes PD, Kirkwood LC, Leppard SW, Redman RP, Tolhurst LA, Stratford PW, Biomaterials, 21, 1847 (2000)
Ohshio M, Ishihara K, Yusa S, Polymer, 11, 327 (2019)
Barthelemy B, Maheux S, Devillers S, Kanoufi F, Combellas C, Delhalle J, Mekhalif Z, ACS Appl. Mater. Interfaces, 6, 10060 (2014)
Ito K, Uchida K, Kitono T, Yamada E, Matsumoto T, Polym. J., 17, 761 (1985)
Tiwari VK, Kulriya PK, Avasthi DK, Maiti P, J. Phys. Chem. B, 113(34), 11632 (2009)
Jeong SH, Yeo SY, Yi SC, J. Mater. Sci., 40(20), 5407 (2005)
Dintcheva NT, Morici E, Arrigo R, La Mantia FP, Polym. J., 46, 160 (2014)
Chon JW, Lee JY, Song JY, Kim JH, Chung DJ, Biomater. Res., 20, 35 (2016)
Pretorius E, Vieira WA, Oberholzer HM, Auer REJ, Int. J. Morphol., 27, 69 (2009)
Cho JY, Kim HK, Song JW, Cheong JW, Shin JW, Yang WI, Kim HO, J. Transl. Med., 16, 199 (2018)
Eikelboom JW, Hirsh J, Thromb. Haemost., 96, 547 (2006)
Mishra DD, Bajpai AK, J. Mater. Sci., Mater. Med., 15, 1921 (2004)

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[1] Lozano M, Cid J, ISBT Sci. Ser., 8, 127 (2013)

[2] Khang G, Lee JH, Lee HB, Polym. Sci. Technol., 7(3), 312 (1996)

[3] Lee JH, Kim KO, Ju YM, Biomed. Mater. Res., 48, 328 (1999)

[4] Maas B, Hurber C, Kramer I, Int. J. Clinical Pharm., 18, 78 (1996)

[5] Park KH, Chung DJ, Biomater. Res., 19, 2 (2015)

[6] Prowse CV, de Korte D, Hess JR, Van der Meer PF, Vox Sang., 106, 1 (2014)

[7] Ishihara K, Iwasaki Y, Nakabayashi N, Mater. Sci. Eng., C6, 253 (1998)

[8] Nakabayashi N, Williams DF, Biomaterials, 24, 2431 (2003)

[9] Lewis AL, Hughes PD, Kirkwood LC, Leppard SW, Redman RP, Tolhurst LA, Stratford PW, Biomaterials, 21, 1847 (2000)

[10] Ohshio M, Ishihara K, Yusa S, Polymer, 11, 327 (2019)

[11] Barthelemy B, Maheux S, Devillers S, Kanoufi F, Combellas C, Delhalle J, Mekhalif Z, ACS Appl. Mater. Interfaces, 6, 10060 (2014)

[12] Ito K, Uchida K, Kitono T, Yamada E, Matsumoto T, Polym. J., 17, 761 (1985)

[13] Tiwari VK, Kulriya PK, Avasthi DK, Maiti P, J. Phys. Chem. B, 113(34), 11632 (2009)

[14] Jeong SH, Yeo SY, Yi SC, J. Mater. Sci., 40(20), 5407 (2005)

[15] Dintcheva NT, Morici E, Arrigo R, La Mantia FP, Polym. J., 46, 160 (2014)

[16] Chon JW, Lee JY, Song JY, Kim JH, Chung DJ, Biomater. Res., 20, 35 (2016)

[17] Pretorius E, Vieira WA, Oberholzer HM, Auer REJ, Int. J. Morphol., 27, 69 (2009)

[18] Cho JY, Kim HK, Song JW, Cheong JW, Shin JW, Yang WI, Kim HO, J. Transl. Med., 16, 199 (2018)

[19] Eikelboom JW, Hirsh J, Thromb. Haemost., 96, 547 (2006)

[20] Mishra DD, Bajpai AK, J. Mater. Sci., Mater. Med., 15, 1921 (2004)