Producing the next generation of thermoset polymers from renewable sources is an important sustainability goal. Hydrogenolysis of pinewood lignin was scaled up for the first time from lab scale to a 50 L pilot-scale reactor, producing a range of depolymerized lignin oils under different conditions. These lignin hydrogenolysis oils were glycidylated, blended with bisphenol A diglycidyl ether, and cured to give epoxy thermoset polymers. The thermal and mechanical properties of the epoxy polymers were assessed by differential scanning calorimetry, thermogravimetric analysis, flexural testing, and dynamic mechanical thermal analysis. Replacing up to 67% of the bisphenol A epoxy with the lignin oil epoxies resulted in cured epoxy polymers with improvements of up to 25% in flexural stiffness and strength. Considerable scope exists in simplifying and scaling up the hydrogenolysis process to produce depolymerized lignins that can substitute established petrochemicals in the quest for renewable high-performance thermoset polymers.