Optimization of an amine-based method is vital to ensure product quality, equipment safety, and system efficiency. Here, the effectiveness of amine concentration and circulation rate is evaluated for a diglycolamine (DGA)-based facility. The performance is measured using the concentration of carbon dioxide in the treated gas and the net acid gas loading of the amine solution. Both amine concentration and circulation rate were observed to affect the system efficiency. An optimal operating range was identified for the gas plant studied established on the performance criteria. The analysis is based on a proprietary mass transfer-based process simulator of an amine-based acid gas treating facility and field data.