Inspired by the polymeric "soft" properties and divisional isolation of tandem processes in natural systems, an artificial reactor with self-screened catalytic ability was fabricated with a polymeric tri-layer architecture. The non-responsive middle layer encapsulated catalytic metal nanoparticles, while the two outer layers consisted of a negatively and a positively thermosensitive imprinted polymer. The inverse responsiveness of the outer layers induced switchable shapes, which led to alterable tandem channeling to the reactive middle layer and, as a result, the divisional admission of different substrates. This way, the reactor led to the formation of self-screened catalytic ability. The design for this artificial reactor offers promising prospects for struggling tandem catalysts, suggesting opportunities to develop schedulable tandem processes.