Liquid dispersion by impacting on wire mesh benefits many mass transfer processes. However, most of studies focused on the dispersion behaviors of liquid impacting on a one-layer wire mesh. In this work, the intensification of droplet dispersion by impacting on multilayer wire mesh was investigated as well as considering the influence of surface wettability. The dispersion characteristics (cone angle of dispersion theta(cone) and average diameter of daughter droplets d(avg)) were systematically analyzed. theta(cone) enlarged by 44% and d(avg) decreased by 12% on average when increasing the water contact angle of the wire mesh from alpha-70 degrees to alpha-155 degrees. Empirical correlations for predicting theta(cone) and d(avg) were proposed. The predicted values agreed well with the experimental data. The intensification of liquid dispersion by using multilayer wire mesh was applied in the inner cavity zone of a rotating packed bed (RPB), leading to a significant improvement of gas-liquid mass transfer performance.