In this contribution, the 5,7-dibromo-8-hydroxyquinoline solubility in neat N,N-dimethylaniline (DMA), n-butanol, methanol, N,N-dimethylforma-mide (DMF), ethanol, 2-butanone, n-propanol, ethyl acetate, isopropanol, acetone, 1-methyl-2-pyrrolidinone (NMP), toluene, and 1,4-dioxolane was experimentally obtained using the shake-flask method covering a temperature range from 288.15 to 328.15 (333.15) K under ambient pressure of p = 101.2 kPa. The solubility values in the mole fraction scale of 5,7-dibromo-8-hydroxyquinoline in the studied thirteen solvents increased as the experimental temperature increased and ranked as NMP > DMA > DMF > 1,4-dioxane > ethyl acetate > toluene > acetone > 2-butanone > n-butanol > n-propanol > ethanol > isopropanol > methanol. The influence of interactions of solvent-solvent molecules and solvent-solute molecules on the 5,7-dibromo-8-hydroxyquinoline solubility was examined by the use of the linear solvation energy relationship according to the solvent descriptors. The obtained solubility data was correlated mathematically through the NRTL model, Ah equation, Apelblat equation, and Wilson model. The acquired values of root-mean-square deviation and relative average deviation were no more than 23.53 X 10(-4) and 5.18 X 10(-2), respectively. In general, the values of relative average deviation attained through the Apelblat equation were smaller than that attained through the other models/equations for a certain neat solvent. The mixing property, infinitesimal concentration activity coefficient, and reduced excess enthalpy were resulted as well.