The synthesis of mixed ligand of cobalt (II) with beta-diketones (beta-dik) (acetylacetone and hexafluoroacetylacetone) and pyrazinamide is proposed. The compounds were investigated by IR- and diffuse reflectance spectroscopies, differential thermal analysis. It is shown that Co (II) beta-diketonates (acetylacetone, hexafluoroacetylacetone) mixed ligand complexes with pyrazinamide have a structure corresponding to a distorted octahedron, having D-4h symmetry. The complexes are bonded through hydrogen bonds via water molecules.