The fabrication of novel scaffolds was represented on the basis of conductive and biodegradable copolymers. The star-like polycaprolactone (S-PCL) was synthesized from dipentaerythritol as a core by a catalyst of Sn(oct)(8) through ring-opening technique. After functionalization of S-PCL by thiophene, thiophene monomer was polymerized from polycaprolactone ends via chemical oxidation polymerization to reach star-like polycaprolactone-polythiophene (S-PCL-PTh). The scaffolds demonstrated a porous configuration (160-190 nm) having the great surface area as well as conductivity of 0.011 S cm(-1). The cytocompatibility measurements exhibited that the nanofibers were not toxic to the MG63 cells.