The goal of this work is an comprehensive experimental validation and verification of a computational CFD-DEM software platform. The software platform's modules and performance requirements specifically address the needs of pharmaceutical industry in terms of batch size (i.e., number of particles) and related phenomena (i.e., physical complexity). Moreover, we critically assessed the numerical models implemented. In addition to the review of relevant literature and selection of validation experiments, novel analytical solutions for the spray class in question are presented. As the presented method is independent of the spray model, the solution can be used to prove the correct implementation of various available spray models. The final outcome of this work is a validated software framework, which can be further used to investigate large-scale processes by resolving single particle trajectories in a coupled environment, including heat, mass and momentum transfer. (C) 2019 Elsevier B.V. All rights reserved.