Numerical modelling of the flow interactions between tidal turbines in arrays is a prerequisite to assess the energy production potential and to optimise the layout of tidal stream energy farms. It requires (i) a refined representation of the tide propagation and (ii) a reliable estimate of the flow characteristics around the turbines. The Actuator Disk (AD) theory is recognised as a reliable parameterisation to approach the far wake of fixed horizontal-axis turbines and was therefore implemented to provide recommendations as regards to the design of arrays, especially the optimal spacing between devices. However, analysis of the arrangement of tidal stream turbines are typically restricted to schematic test cases with idealised bathymetry and inflow conditions. The present study aims to investigate the flow interactions between turbines in a stream energy site with spatially- and time-varying tidal conditions. The site of application is the Alderney Race (English Channel), an area with strong potential for the exploitation of tidal energy in European shelf seas. The three-dimensional numerical model Telemac3D is used to capture the flow at both the regional and the array scales. Predictions are first assessed against ADCP measurements acquired around the island of Alderney. A series of simulations, representing turbines with the AD theory, are then performed to investigate the influence of the wake interactions on the energy production of individual devices. In those simulations, the turbines are represented with the AD theory. The zone occupied by the turbines is 20D-long and 15D-wide (D is the turbine diameter). Different layouts (isolated, aligned and staggered turbines) and different longitudinal and lateral spacings are considered to investigate the effect of the turbines' arrangement and density on the array energy production. The results show that, for a given turbines density within the array, the staggered layout produces more than the aligned layout (+16%). When the turbines are staggered, a minimal lateral spacing of 5D is required to avoid wake overlapping. However, when the turbines are aligned, the lateral spacing has a small influence on the turbines production. It is therefore possible to pack the turbines close to each other in the lateral direction. The simulations also outline that the turbulence develops much faster within the array when the turbines are aligned. (C) 2019 Elsevier Ltd. All rights reserved.