In order to solve the water and energy crisis problem, the thermal water desalination and parabolic trough solar collectors are used at the cogeneration plants. In this paper, an integrated structure for cogeneration of fresh water and power has been developed using a multi-stage thermal water desalination system and organic Rankine cycle. In order to supply the input heat, an integrated structure of parabolic trough solar collectors, and to supply the condenser cooling of organic Rankine cycle, the re-gasification operations have been used. This integrated structure is capable of fresh water generation of 3628 kgmol/h and electrical power of 459.9 MW. In this integrated structure, the efficiency of the organic Rankine cycle power plant and gain output ratio of the multi effect desalination system is 12.47% and 2.918, respectively. Exergy analysis has been used to examine the second law of thermodynamics and the quality of the integrated structure. The total exergy efficiency of the integrated structure is 87.11%, and also, the highest share of equipment exergy destruction is related to the heat exchangers and collectors by 50.23% and 38.18%, respectively. In order to simulate the dynamics of the integrated structure, according to the input climatic information of the studied location in Tehran, Iran. Furthermore, decisions are made upon the sensitivity analysis on economic important indicators within an integrated structure. (C) 2019 Elsevier Ltd. All rights reserved.