In this study, mesoporous CdO-graphene and mesoporous TiO2 were successfully synthesized using a facile method. The results indicated that photocatalytic activity can be enhanced with the combination of mesoporous CdO-graphene and mesoporous TiO2. The photocatalytic performance of the mesoporous CdO-graphene-TiO2 photocatalyst presents significantly improved photocatalytic activity of safranine O, reactive black B, and GA due to the improvement of the surface area and the small average pore size distribution of the as-prepared mesoporous CdO-graphene-TiO2. The photodegradation rate was optimized by safranine O at a pH solution of 11 and by GA at the dosage amount of 0.07 g photocatalyst.