The supercritical fluid extraction of Carica papaya linn. leaves in the presence of CO2 solvent and ethanol modifier was carried out with respect to four operating parameters, namely temperature (40-60 degrees C), pressure (18-30 MPa), solvent flow rate (3-6 mL/min) and co-solvent ratio (3 - 5 vol%), for the maximization of global extract yield of Carica papaya linn. leaves. The optimized parameters obtained are as follows: temperature of 57.47 degrees C, pressure of 26.62 MPa, solvent flow rate of 5.43 mL/min and co-solvent ratio of 4.98% with a predicted global extract yield of 0.0806 g. Five density-based solubility models, namely Chrastil, Bian et al., Bartle et al., Sparks et al. and Mendez-Santiago and Teja models were correlated against experimental solubility data. The Mendez-Santiago and Teja model were found to be more accurate with AARD of 1.36% and R-2 value of 0.873 due to the non-linearity extraction profiles of papaya leaves. (C) 2020 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.