Chemistry Letters, Vol.49, No.6, 709-712, 2020
Efficient Synthesis of Substituted Morpholine Derivatives via an Indium(III)-catalyzed Reductive Etherification Reaction
An efficient synthesis of morpholine derivatives has been developed using indium(III)-catalyzed intramolecular reductive etherification reaction. This method allows the construction of various 2-substituted, and 2,3-, 2,5-, 2,6-disubstituted morpholines with good to excellent yields and high diastereoselectivity. In addition, this method demonstrates good compatibility with a broad range of functional groups.