Work and heat are the two major forms of energy consumption in the process industry. They are respectively consumed in the work exchange and heat exchange networks. Because of the tight interactions between these two networks, a growing number of researchers tend to consider them as a whole: work and heat exchange networks (WHENs). However, this is a complicated system that includes not only pressure manipulation units but also heat exchangers. To synthesize such a complicated system, we propose a two-phase strategy: targeting and design. In the targeting phase, the optimal thermodynamic paths of process streams are determined by optimizing the utility consumption and estimated capital investments. To represent possible thermodynamic paths of unclassified process streams, we propose a novel stage-wise superstructure where the utility consumption and heat exchanger area of the HEN part are estimated by an extended pinch analysis method under the assumption of vertical heat transfer. With obtained thermodynamic paths, the HEN synthesis problem in the design phase is carried out by the well-known stage-wise superstructure (SWS) model. Two literature examples are presented to illustrate the effectiveness and applicability of the proposed method. In two case studies, our approach yields WHENs with 30.7 and 28.3% lower total annual cost, respectively.