Ce1-3xCuxFexZnxO2 nano-particles were synthesized by hydrothermal method. The micro-structure, spectra features and catalysis effects on hydrogen storage alloy of Ce1-3xCuxFexZnxO2 were studied. It was researched that the dopants were inserted into the lattice of CeO2 and the solid solubility x was identified as 0.05. The oxygen vacancies contents and degree of lattice distortion were improved, and the band gap energies were decreased. The hydrogen absorption/desorption kinetics of Mg60La10Ni20-5 mol%Ce1-3xCuxFexZnxO2 composites were evaluated. The results showed that the catalysts effects were improved by enhancing the doped concentrations. The catalysis mechanism was related with the microstructure and micro-electronic structure of the catalysts.