Among the few lessons learned presented in the literature, authors put in evidence the ongoing need to investigate on station components and their integration. The specific power consumption of station units with on-site hydrogen generation is often subject to uncertainty, and it would have been desirable to find more details about the energy contribution of each component. To address this gap, this paper focuses on the development of a mathematical modeling as a dynamic and multi-physical design tool to predict the energy performance of hydrogen production systems. Particularly, the model aims to describe and analyze the energy performance of two different electrolyzer technologies (PEM and Alkaline), integrated with a compressor system and gaseous buffer storage. Multiple tank options and a switching strategy are investigated, as well as a control system to simulate a real infrastructure operation. Auxiliaries and components related to the thermal management system have been also included. A carbon-footprint analysis follows the energy one, focusing on the CO2 emission reduction. Comparisons between literature data and model show that the hydrogen system proposed model is suitable to evaluate systems with respect to energy efficiency and system performance. The model could be a powerful tool for exploring control strategies and understanding the contributions to the overall energy consumption from the various internal components as a guide to researchers aiming for improved performance. (C) 2020 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.