Organic-inorganic hybrid nano-material has a significant potential for enhancing the charge separation efficiency of photocatalyst. However, it remains an important issue to controllable synthesis new hybrid system with unique structure and earth-abundant materials for boosting photocatalytic hydrogen revolution. We report a facile one-step hydrothermal strategy to fabricate a novel Titania/beta-cyclodextrin (TiO2/beta-CD) organic-inorganic hybrid nano-material with an alveolate structure. In this hybrid system, beta-CD not only played a critical role in alveolate structure formation, but also served as a bridge connecting target molecular and active sites on the TiO2 surface to facilitate the separation and transfer of the photoexcited electrons with prolonged lifetime. As a result, this alve-olate TiO2/beta-CD composite exhibited outstanding photocatalytic activity and a H-2 evolution rate of 725 mu mol/g-h was achieved over TiO2/beta-CD which was 14 times of bare TiO2 under simulated sunlight. This work paves a way for controllable synthesis of novel organicinorganic hybrid nano-material with distinct structure for efficient photocatalysis. (C) 2020 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.