In the liquid dispersion structure, pure methanol, ethanol, isopropanol, and N,N-dimethyl formamide (DMF) play a major role in dissolution and then water was added in sequence for dilution to obtain a dispersion system with different composition structures, and the concentration gradient between each mixed liquid was 0.1 (mass fraction). The drug nicorandil whose solubility was to be tested is added to it, using the isothermal method, with a high temperature of 323.15 K as the starting point and an interval of 5 K to a low temperature of 278.15 K. The pressure conditions did not require special requirements in an ordinary atmospheric pressure environment (101.1 kPa). Results show that when the temperature approaches the high level, more drugs can be dissolved in the same amount of solvent. Conversely, when the temperature was close to the low level, the drug is more difficult to dissolve. If the temperature was constant and the proportion of the organic solvent was large, the dissolving capacity of the dispersion system will develop in a positive direction. Conversely, if the proportion of water was large, the dissolving power will decrease. Nicorandil crystals accepted the determination of various dissolution data including undissolved raw materials have undergone X-ray power diffraction detection. The results obtained were gratifying, and no change in the crystal structure of the substance was found. Three models-Jouyban-Acree model, Van't Hoff-Jouyban-Acree model, and modified Apelblat-Jouyban-Acree model-were employed to calculate the experimental nicorandil solubility, and relative average deviation and root-mean-square deviation were no higher than 0.88 and 1.69 X 10(-4) , respectively. The research on nicorandil is not only a simple measurement of the dissolution data but also more important is that with the support of these data, more thermodynamic data can be calculated to study nicorandil, which is for the improvement of the production process of nicorandil and the synthesis of pharmaceutical preparations is an indispensable link.