The equilibrium solubility of amrinone in solvent mixtures of methanol + water, ethanol + water, N,N-dimethylformamide (DMF,) + water, and ethylene glycol (EG) + water was determined experimentally. The drug amrinone whose solubility is to be tested is added to it, using the isothermal method with a high temperature of 323.15 K as the starting point and an interval of 5 K to a low temperature of 278.15 K. The pressure conditions do not require special requirements at an ordinary atmospheric pressure environment (101.1 kPa). Results show that when the temperature approaches the high level, more drugs can be dissolved in the same amount of solvent. Conversely, when the temperature is close to the low level, the drug is more difficult to dissolve. If the temperature is constant and the proportion of organic solvent is large, then the dissolving capacity of the dispersion system will develop in a positive direction. Conversely, if the proportion of water is large, the dissolving power will decrease. Amrinone crystals accepted the determination of various dissolution data including undissolved raw materials that have undergone X-ray power diffraction (XPRD) detection. The results obtained are gratifying; no change in the crystal structure of the substance is found. In addition, the solubility of amrinone was correlated with the Jouyban-Acree model, van't Hoff-Jouyban-Acree model, and Apelblat-Jouyban-Acree model and RAD and RMSD were no higher than 1.28% and 1.0 x 10(-6), respectively. The research on amrinone is not only a simple measurement of the dissolution data but also more important is that with the support of this data, more thermodynamic data can be calculated to obtain amrinone, which is for the improvement of the production process of amrinone and the synthesis of pharmaceutical preparations is an indispensable link.