The resistivity and magnetoresistance of multi-walled carbon nanotubes with different degrees of structural perfection in the temperature interval from 4.2 K to 293 K and in the magnetic field up to 2 T are investigated. The revealed anomalies of the temperature and field dependences of resistivity of multi-walled carbon nanotubes are analyzed in the terms of charge carrier's weak localization and interaction effects for two-dimensional systems. For carbon nanotubes with different degrees of structural perfection diffusion coefficient, charge carrier's interaction parameter and the value of the Fermi energy are estimated. It is shown that the anomalies found in the resistivity and magnetoresistance for the defective multi-walled carbon nanotubes are related with the manifestation of the weak localization effect, while for the multi-walled carbon nanotubes of the perfect structure these anomalies are explained by the charge carriers interaction effect.