In current research, turbulent thermal behavior of CuO-Distilled H2O based nanomaterial resulting from inserting a novel turbulator has been modeled. Considering four different cases having different geometries, which are the plain tube (PT), twisted tape (TT), barrier twisted tape (BIT), perforated barrier twisted tape (PBTT), and applying the two-phase mixture model (TPMM) for CuO-water nanomaterial at constant volume fraction as well as various Reynolds numbers have been investigated. Intensify of turbulence with the addition of barriers, leading to significant heat transfer enhancement. From another point of view, with placing barriers on twisted tapes, pressure drop increases. However, the PBTT case has much less pressure drop than the BIT case, which shows the higher efficiency in the PBTT case, leading to reducing the cost of energy. Moreover, more particle accumulation has been detected in the PBTT case, which can also positively affect heat transfer improvement. (C) 2020 Elsevier B.V. All rights reserved.