This study focuses on the effect of the riser lateral vibration on the pressure loss of coarse particles hydraulic lifting by the numerical simulation. Euler-Euler two-fluid model based on kinetic theory is used to simulate the flow behavior of coarse particles in the riser, and the numerical model has been validated by using the experimental data. The dynamic grid technique is employed to simulate the lateral vibration of the riser. According to results of numerical simulation, the lateral vibration leads to the cyclical fluctuation of the pressure loss of coarse particles hydraulic lifting, and the average pressure loss of the dynamic riser is bigger than the static riser in general. The influence of the vibration amplitude, vibration period and modal shape on the pressure loss is analyzed, and the cause of pressure loss is also discussed. (C) 2020 Elsevier B.V. All rights reserved.