Mechanically stirred slurry tanks are utilized in several industries to perform various unit operations such as crystallization, adsorption, ion-exchange, suspensions polymerization, dispersion of solid particles, leaching and dissolution, and activated sludge processes. The major goal of this review paper is to critically and thoroughly analyse the different aspects of previous research works reported in the literature in the field of liquid-solid mixing. This paper sheds light on the advantages and limitations of various particle concentration measurement methods employed to assess the suspension quality and the extent of solid suspensions in slurry reactors. Attempts are being made to identify and compare various mathematical models and methods to quantify particle dispersion and distribution in slurry reactors. It has been shown that various factors such as geometric configurations, agitation conditions, and physical characteristics of liquid and solid have pronounced influence on local suspension quality and power consumption. Computational fluid dynamics (CFD) modeling can be extremely useful in assessing the suspension of solid particles in slurry tanks. A critical review of different scale-up procedures employed for solid suspension and distribution in liquid-solid systems is presented as well. The findings of this review paper can be useful for future research works in liquid-solid mixing.