이온성 천연다당류가 다공성 수화젤 콘택트렌즈의 기능 향상에 미치는 영향

고나영; 이현미; Na-Young Ko; Hyun Mee Lee

Polymer(Korea), Vol.44, No.5, 625-632, September, 2020

DOI10.7317/pk.2020.44.5.625 Export Citation

이온성 천연다당류가 다공성 수화젤 콘택트렌즈의 기능 향상에 미치는 영향

Effect of Ionic Natural Polysaccharides on the Functional Enhancement of Porous Hydrogel Contact Lenses

고나영, 이현미^†

대구가톨릭대학교 안경광학과

Na-Young Ko, and Hyun Mee Lee^†

Department of Optometry & Vision Science, Catholic University of Daegu, Hayang-Ro 13-13, Gyeongsan, Gyeongbuk 38430, Korea

E-mail:

초록

다공성 수화젤 콘택트렌즈를 제작한 후 이온성 천연다당류를 가교시켜 이온성 천연다당류가 콘택트렌즈의 물리적?화학적 성질에 미치는 영향을 알아보고자 하였다. 다공성 수화젤은 발포제로서 sodium carbonate를 사용하였으며 이온성 천연다당류로서 alginate, chitosan, agarose를 사용하였다. 다공성 수화젤은 일반 수화젤보다 함수율, 산소투과율, 습윤성이 매우 향상되었다. 천연다당류가 결합된 콘택트렌즈는 이온성의 종류에 관계없이 모든 다공성 콘택트렌즈에서 습윤성과 항균성을 향상시켰다. 콘택트렌즈의 단백질 흡착은 다당류의 이온성에 영향을 받았다. 이온성 천연다당류가 수화젤 콘택트렌즈에 결합됨으로써 콘택트렌즈의 기능향상에 기여함을 확인하였다.

The purpose of this study was to examine the effect of ionic natural polysaccharides on the physico-chemistry properties of contact lenses by cross-linking ionic natural polysaccharides after fabricating porous hydrogel contact lenses. Sodium carbonate was used as a foaming agent in the preparation of porous hydrogels, and ionic natural polysaccharides such as alginate, chitosan, and agarose were used. Porous hydrogels have significantly improved water content, oxygen permeability, and wettability than ordinary hydrogels (polymacon). Natural polysaccharide cross-linked contact lenses have improved wettability and antibacterial properties in all porous contact lenses, regardless of their ionic type. Protein adsorption of contact lenses was affected by the ionicity of polysaccharides. It was confirmed that the ionic natural polysaccharide contributes to the improvement of the function of the contact lens by being bound to the hydrogel contact lens.

Keywords:contact lens;foaming agent;natural polysaccharide;oxygen permeability;porous hydrogel

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[2] Omidian H, Rocca JG, Park K, J. Control. Release, 102, 3 (2005)

[3] Nagpal M, Singh SK, Mishra D, Acta Pharm. Sci., 53, 7 (2011)

[4] Kumari M, Chauhan GS, J. Appl. Polym. Sci., 363, 119 (2011)

[5] Thakur VK, Thakur MK, J. Clean. Prod, 82, 1 (2014)

[6] Lin CC, Metters AT, Adv. Drug Deliv. Rev., 58, 1379 (2006)

[7] Hamidi M, Azadi A, Rafiei P, Adv. Drug Deliv. Rev., 60, 1638 (2008)

[8] Lee KY, Mooney DJ, Prog. Polym. Sci, 37, 106 (2012)

[9] Shapiro L, Cohen S, Biomaterials, 18, 583 (1997)

[10] Whang HS, Kirsch W, Zhu YH, Yang CZ, Hudson SM, J. Macromol. Sci.-Polym. Rev, 45, 309 (2005)

[11] Goy RC, Britto DD, Assis OB, Polimeros, 19, 241 (2009)

[12] Makarios-Laham I, Lee TC, J. Environ. Polym. Degrad., 3, 31 (1995)

[13] Thorat ND, Otari SV, Patil RM, Bohara RA, Yadav HM, Koli VB, Ningthoujam RS, Dalton T, 43, 17343 (2014)

[14] de Britto D, Assis OB, Carbohydr. Polym., 69, 305 (2007)

[15] Rossi F, Santoro M, Casalini T, Veglianese P, Masi M, Perale G, Int. J. Mol. Sci., 12(6), 3394 (2011)

[16] Kim SJ, Park SJ, Kim SI, React. Funct. Polym., 53, 55 (2003)

[17] Zhao Y, Kang J, Tan TW, Polymer, 47(22), 7702 (2006)

[18] Sangermano M, Cook WD, Papagna S, Grassini S, Eur. Polym. J., 48, 1796 (2012)

[19] Omidian H, Rocca JG, Park K, Macromol. Biosci., 6, 703 (2006)

[20] Gao B, Hu H, Guo J, Li Y, Colloids Surf. B: Biointerfaces, 77, 206 (2010)

[21] Ghazali S, Adnan N, Indian J. Sci. Technol., 10, 1 (2017)

[22] Chavda H, Patel C, J. Pharm. Bioallied Sci., 2, 124 (2010)

[23] Avila A, Bierbrauer K, Pucci G, Lopez-Gonzalez M, Strumia M, J. Food Eng., 109(4), 752 (2012)

[24] Vardar E, Vert M, Coudane J, Hasirci V, Hasirci N, J. Biomater. Sci. Polym. Ed., 23, 2273 (2012)

[25] Hennink WE, Talsma H, Borchert JCH, De Smedt SC, Demeester J, J. Control. Release, 39, 47 (1996)

[26] Compan V, Andrio A, Lopez-Alemany A, Riande E, Refojo MF, Biomaterials, 23, 767 (2002)

[27] Hoffman AS, Adv. Drug Deliv. Rev., 54, 3 (2002)

[28] Efron N, Morgan PB, Cameron ID, Brennan NA, Goodwin M, Optom. Vis. Sci., 84, E328 (2007)

[29] Pozuelo J, Compan V, Gonzalez-Meijome JM, Gonzalez M, Molla S, J. Membr. Sci., 452, 62 (2014)

[30] Ito A, Sato M, Anma T, Macromol. Chem. Phys., 248, 85 (1997)

[31] Bruce AS, Mainstone JC, Golding TR, Biomaterials, 22, 3249 (2001)

[32] Iwasaki Y, Ishihara K, Sci. Technol. Adv. Mat., 13, 064101 (2012)

[33] Awadhiya A, Tyeb S, Rathore K, Verma V, Eng. Life Sci., 17, 204 (2017)

[34] Elder MJ, Stapleton F, Evans E, Dart JK, Eye, 9, 102 (1995)

[35] Junter GA, Thebault P, Lebrun L, Acta Biomater, 30, 13 (2016)

[36] Dufrene YF, Boonaert CJP, Rouxhet PG, Colloids Surf. B: Biointerfaces, 7, 113 (1996)

[37] Jalbert I, Willcox MD, Sweeney DF, Cornea, 19, 116 (2000)

[38] Lee HM, Kim JK, Cho TS, Bull. Korean Chem. Soc., 32, 4239 (2011)

[39] Cushnie TT, Hamilton VE, Lamb AJ, Microbiol. Res., 158, 281 (2003)

[40] Badawy MEI, Rabea EI, Int. J. Carbohydr. Chem., 2011, 460381 (2011)

[41] Jia Z, Xu W, Carbohydr. Res., 333, 1 (2001)

[42] Luensmann D, Jones L, Contact Lens Anterior., 31, 179 (2008)

[43] Luensmann D, Jones L, Contact Lens Anterior., 35, 53 (2012)

[44] Soltys-Robitaille CE, Ammon DM, Valint PL, Grobe GL, Biomaterials, 22, 3257 (2001)