화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Korean Journal of Chemical Engineering, Vol.37, No.10, 1732-1742, October, 2020
DOI10.1007/s11814-020-0591-5  Export Citation
Effect of molecular weight of regenerated silk fibroin on silk-based spheres for drug delivery
Zengkai Wang, Xiangming Li, Yanhua Cui, Kai Cheng, Mingdong Dong1, and Lei Liu†
  • School of Materials Science and Engineering and Institute for Advanced Materials, Jiangsu University, Zhenjiang, 212013, China
  • 1Interdisciplinary Nanoscience Center (iNANO), Aarhus University, DK-8000 Aarhus C, Denmark
E-mail:
Silk fibroin presents a good advantage as a drug carrier for drug delivery, due to the excellent biocompatibility, biodegradability and tunable drug loading and release properties. In this work, we constructed silk spheres by phase separation of the regenerated silk fibroin (RSF) solutions with different MW and polyvinyl alcohol; and it was revealed that MW of RSF can affect the structure, size, surface potential and drug loading and release efficiency of silk spheres. Silk spheres prepared from high MW of RSF were found to load more macromolecular drug with negative charge compared to middle and low MW of RSF. However, for the positive charge and low MW drug, the silk spheres prepared from low MW of RSF could present a high loading efficiency compared to other carriers. Finally, a positive drug with low MW, streptomycin was encapsulated in silk spheres prepared from low MW of RSF, and displayed a long bactericidal and bacteriostatic effect compared to bared streptomycin solution. The results obtained provide guidelines for the modification and options of drug transport vehicles for more efficient drug delivery and utilization through a simple, rapidly constructed, applicable and low-cost drug carrier.
Keywords:Silk Fibroin;Encapsulation and Release;Release Kinetics;Streptomycin;Antibactericidal Material
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