화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Applied Chemistry for Engineering, Vol.31, No.5, 532-538, October, 2020
DOI10.14478/ace.2020.1067  Export Citation
녹차추출물이 함유된 천연 자외선차단 크림의 제조: CCD-RSM을 이용한 최적화
Emulsification of Natural Sunscreen with Green Tea Extract : Optimization Using CCD-RSM
이승범, 줘청량, 쉬 양, 홍인권†
  • 단국대학교 화학공학과
Seung Bum Lee, Chengliang Zuo, Yang Xu, and In Kwon Hong†
  • Department of Chemical Engineering, Dankook University, Yongin 16890, Korea
E-mail:
초록
본 연구에서는 천연 자외선 차단크림을 제조하기 위해 shea butter, 올리브 유화왁스, 녹차추출물 등을 원료로 유화과정을 수행하였다. 유화과정의 최적화는 CCD-RSM을 이용하여 진행하였으며, 반응치로는 유화액의 7 days 경과 후 평균액적크기(MDS), 유화안정도지수(ESI), 300 nm에서의 자외선 흡광도 등을 설정하였다. 실험에 사용된 독립변수로는 유화제의 첨가량, 녹차추출물의 첨가량 및 유화시간을 설정하였다. CCD-RSM에 의해 최적화과정을 수행한 결과 자외선 차단크림 O/W 유화공정의 최적조건은 유화제의 첨가량(3.70 wt.%), 녹차추출물의 첨가량(2.47 wt.%) 및 유화시간(15.4 min)이었으며, 이때 예측된 반응치는 7 days 경과 후 유화액의 MDS (1173.8 nm), ESI (99.56%), 그리고 300 nm에서의 자외선 흡광도(2.47)로 나타났다. 이 조건에서의 실제실험 결과 오차율은 3.0 ± 1.5%로 낮게 나타나 본 연구에서 적용 된 CCD-RSM 최적화 과정이 비교적 높은 유의수준으로 나타난 것으로 판단된다.
In this study, emulsification process were conducted to manufacture the natural sunscreen from raw materials such as shea butter, olive emulsifier wax, and green tea extract. The emulsification was optimized by using the central composite design model-response surface methodology (CCD-RSM) where the response values were established as the mean droplet size (MDS) and emulsion stability index (ESI) after 7 days in addition to UV absorbance at 300nm. The amount of emulsifier and additives and emulsification time were established as operating variables and the optimal conditions of sunscreen emulsification were accepted as 3.70, 2.47 wt.%, and 15.42 min, respectively according to the result of CCD-RSM. On the other hand, the response values were estimated as 1173.80 nm and 99.56% for MDS and ESI, respectively, after 7 days, in addition to UV absorbance at 300 nm (2.47). The average error from actual experiments was a low level as about 3.0 ± 1.5%, which is mainly due to the fact that the optimization using CCD-RSM applied in this study was in the relatively high significant level.
Keywords:Natural sunscreen;Central composite design model;Emulsion stability;UV absorbance
  1. Cavinato M, Waltenberger B, Baraldo G, Grade CVC, Stuppner H, Jansen-Durr P, Biogerontology, 18(4), 499 (2017)
  2. Liang X, TAIYUAN SCI-TECH, 10 (2009)
  3. Katiyar SK, Cancer Lett., 255(1), 1 (2007)
  4. Nigam PK, Indian J. Dermatol. Venereol. Leprol., 75, 10 (2009)
  5. Chen PF, The Light & Textile Industries of Fujian, 12, 1-4 (2003).
  6. Soter NA, Semin Dermatol., 9(1), 11 (1990)
  7. Pauli ED, Scarmino IS, Tauler R, J. Chemom., 30, 75 (2016)
  8. Einspahr JG, Bowden GT, Alberts DS, Recent Results Cancer Res., 163, 151 (2003)
  9. Morley N, Clifford T, Salter L, Campbell S, Gould D, Curnow A, Photodermatol. Photoimmunol. Photomed., 21, 15 (2005)
  10. Katiyar SK, Curr Drug Targets Immune Endocr Metabol Disord., 3(3), 234-242 (2003).
  11. Yang X, Chen L, Lu HM, Yang SQ, An JJ, Science and Technology of Food Industry, 40(5), 322-328, 332 (2019).
  12. Berne BJ, Pecora RD, Courier Corporation (2000).
  13. Chalapud MC, Baumler ER, Carelli AA, Food Res. Int., 108, 216 (2018)
  14. Pearce NK, Kinsella JE, J. Agric. Food Chem., 26(3), 716 (1978)
  15. Saeed MO, Azizli K, Isa M, Bashir MJK, J. Water Process Eng., 8, 7 (2015)
  16. Yolmeh M, Najafi MBH, Farhoosh R, Food Chem., 155, 319 (2014)