An elaborate sensor system based on conducting polymer-oligosaccharides in hydrogel and the formation of inclusion complexes

Joonwon Bae; Yunjung Hwang; Sung-Hoon Park; Seon Joo Park; Jiyeon Lee; Hye Jun Kim; Ayeon Jang; Soyeon Park; Oh Seok Kwon

Journal of Industrial and Engineering Chemistry, Vol.90, 266-273, October, 2020

DOI10.1016/j.jiec.2020.07.023 Export Citation

An elaborate sensor system based on conducting polymer-oligosaccharides in hydrogel and the formation of inclusion complexes

Joonwon Bae^†, Yunjung Hwang¹, Sung-Hoon Park², Seon Joo Park³, Jiyeon Lee³, Hye Jun Kim, Ayeon Jang, Soyeon Park, and Oh Seok Kwon^{3, †}

Department of Applied Chemistry, Dongduk Women's University, Seoul 02748, Republic of Korea
¹Bionanotechnology Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB), 125 Gwahak-Ro, Yuseong-Gu, Daejeon 34141, Republic of Korea
²Department of Mechanical Engineering, Soongsil University, Seoul 06978, Republic of Korea
³Infectious Disease Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB), 125 Gwahak-Ro, Yuseong-Gu, Daejeon 34141, Republic of Korea

E-mail:,

In this study, electrically conductive materials composed of carboxylated polypyrrole (PPy(COOH)) and nontoxic oligosaccharide molecules (cyclodextrin, CD) were prepared and incorporated into biocompatible hydrogels for use as versatile sensors. The major component, carboxylated polypyrrole nanotubes (PPy(COOH) NTs) were fabricated using microemulsion polymerization and a critical sensing medium CD molecule was introduced via a simple surface engineering method. The resulting PPy (COOH)-CD NT hybrid complexes were incorporated into a hydrogel matrix for biocompatible applications. Consequently, a convenient sensor geometry was constructed by mounting the hydrogel on a gold micropattern for the detection of toxic substances. The feasibility of the produced sensor system was demonstrated, and the sensor performance was measured extensively using electrical measure-ments. It was found that the sensor could detect a model compound (methyl paraben, MPRB) at concentration as low as 1 nM. This study provides useful information for future research activities in relevant fields.

Keywords:Polypyrrole;Cyclodextrin;Hydrogel;Chemical sensor;Inclusion complex

[References]

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[1] Bae JW, Shin KS, Kwon OS, Hwang YJ, An JE, Jang AY, Kim HJ, Lee CS, J. Ind. Eng. Chem., 79, 19 (2019)

[2] Kwon OS, Song HS, Park SJ, Lee SH, Ah JH, Park JW, Yang H, Yoon H, Bae J, Park TH, Jang J, Nano Lett., 15, 6559 (2015)

[3] Kwon OS, Lee SH, Park SJ, An JH, Song HS, Kim T, Oh JH, Bae J, Yoon H, Park TH, Jang J, Adv. Mater., 25(30), 4177 (2013)

[4] An JH, Park SJ, Kwon OS, Bae J, Jang J, ACS Nano, 7, 10563 (2013)

[5] Hwang YJ, Park JY, Lee CS, Kwon OS, Park SH, Bae J, Compos. Pt. A-Appl. Sci. Manuf., 107, 55 (2018)

[6] Bae J, Hwang YJ, Park SJ, Ha JH, Kim HJ, Jang AY, An J, Lee CS, Park SH, Polymers, 10, 951 (2018)

[7] Hwang Y, Park JY, Kwon OS, Joo S, Lee CS, Bae J, Appl. Surf. Sci., 429, 258 (2018)

[8] Huh J, Park SH, Bae J, Curr. Org. Chem., 19, 1117 (2015)

[9] Adhikari A, De S, Halder A, Pattanayak S, Dutta K, Mondal D, Rana D, et al., Synth. Met., 245, 209 (2018)

[10] Lee CY, Hsu DY, Prasannan A, Kalaivani R, Hong PD, Appl. Surf. Sci., 363, 451 (2016)

[11] Lin M, RSC Adv., 5, 9848 (2015)

[12] Mahmoudian MR, Basirun WJ, Alias YB, Ind. Eng. Chem. Res., 55(25), 6943 (2016)

[13] Zhou X, Ma P, Wang A, Yu C, Qian T, Wu S, Shen J, Biosens. Bioelectron., 64, 404 (2015)

[14] Niu X, Yang X, Mo Z, Liu N, Guo R, Pan Z, Liu Z, Microchim. Acta, 186, 557 (2019)

[15] Santos ES, Reis VS, Guimaraes L, Nascimento CS, Chem. Phys. Lett., 730, 141 (2019)

[16] Lukasek J, Rezankova M, Stibor I, Rezanka M, J. Incl. Phenom. Macrocycl. Chem., 92, 339 (2018)

[17] Ma X, Li X, Shi J, Yao M, Zhang X, Hou R, Shao N, Luo Q, Gao Y, Du S, Liang X, Wang F, Adv. Healthc. Mater., 8, 190066 (2019)

[18] Liu L, Han Y, Lv S, ACS Appl. Mater. Interfaces, 11, 20394 (2019)

[19] Deng Z, Guo Y, Zhao X, Ma PX, Guo B, Chem. Mater., 30, 1729 (2018)

[20] Harley C, Annibaldi V, Yu T, Breslin CB, J. Electroanal. Chem., 855, 113614 (2019)

[21] Hendy GM, Breslin CB, J. Polym. Res., 26, 61 (2019)

[22] Wajs E, Fernandez N, Fragoso A, Analyst, 141, 3274 (2016)

[23] Shishkanova TV, et al., Electroanalysis, doi: 10.1002/elan.201900615.

[24] Palanisamy S, Thangavelu K, Chen SM, Velusamy V, Chang MH, Chen TW, Al-Hemaid FMA, Ali MA, Ramajay SK, Sens. Actuators B-Chem., 243, 888 (2017)

[25] Fritea L, Gorgy K, Le Goff A, Audebert P, Galmiche L, Sandulescu R, Cosnier S, J. Electroanal. Chem., 781, 36 (2016)

[26] Park SJ, Song HS, Kwon OS, Chung JH, Lee SH, An JH, Ahn SR, Lee JE, Yoon H, Park TH, Jang J, Sci. Rep., 4, 4342 (2014)

[27] Yang JH, Kim HT, Kim H, Micro Nano Syst. Lett., 2, 1 (2014)

[28] Bae J, Hur JH, Sci. Adv. Mater., 8, 176 (2016)

[29] Park MJ, Kim SY, Bae JW, Appl. Chem. Eng., 29(5), 519 (2018)

[30] Park SJ, Lee J, Seo S, Kim KH, Park CS, Lee SH, Ban HS, Lee BD, Lee CS, Bae J, Sci. Rep., 10, 3772 (2020)

[31] Liu L, Song KS, Li XS, Guo QX, J. Incl. Phenom. Macrocycl. Chem., 40, 35 (2001)

[32] Seokham P, Do TT, Van den Mooter G, Loftsson T, J. Incl. Phenom. Macrocycl. Chem., 90, 111 (2018)

[33] Khalid WEFW, Arip MNM, Jasmani L, Lee YH, Sensors, 19, 2726 (2019)