화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Polymer(Korea), Vol.44, No.6, 784-789, November, 2020
DOI10.7317/pk.2020.44.6.784  Export Citation
한 용기 내 중합반응에 의한 금 나노입자를 함유한 PEG 수화젤 입자의 합성
Preparation of Poly(ethylene glycol) Hydrogel Particles Containing Gold Nanoparticles by In Situ Polymerization
김연희, 김범상†
  • 홍익대학교 화학공학과
Youn-Hee Kim, and Bumsang Kim†
  • Department of Chemical Engineering, Hongik University, Wausanro 94, Mapo-gu, Seoul 04066, Korea
E-mail:
초록
금 입자와 고분자 입자를 결합한 유무기 복합재료를 컴퓨터단층촬영(CT)의 조영제로 사용하기 위한 첫 단계로, PEG 수화젤 입자 내부에 금 나노입자를 고농도로 탑재하여 최종적으로 합성된 Au-PEG 수화젤 입자의 CT세기를 향상시킬 수 있는 합성방법을 개발하였다. 다양한 방법을 이용하여 Au-PEG 수화젤 입자를 제조한 결과, PEG 수화젤 입자를 중합하는 동안 금 나노입자를 수화젤 내부에 탑재하는 한 용기내 중합(in situ 법)을 사용할 경우, 가장 높은 CT세기를 보이고 탑재된 금 입자가 수화젤로부터 방출되지 않는 안정적인 Au-PEG 수화젤 입자를 합성할 수 있었다. In situ법을 사용하여 입자를 제조할 경우, 투입한 금 전구체의 농도가 증가할수록 그리고 중합과정에서 1차 중합시간이 증가할수록, 합성된 Au-PEG 수화젤 입자의 CT세기가 증가하였으며, 비이온성 계면활성제를 분산안정제로 사용할 경우, 가장 높은 CT세기를 가지는 입자를 제조할 수 있었다.
As the first step to use an organic/inorganic composite combining gold nanoparticles (AuNPs) and polymer particles as a contrast agent for computed tomography (CT), PEG hydrogel particles containing AuNPs, Au-PEG hydrogel particles, were prepared and the synthetic conditions were established to improve the CT intensity of the Au-PEG hydrogel particles. Au-PEG hydrogel particles that had the highest CT intensity were obtained and the encapsulated AuNPs were not released from the hydrogel particles when Au-PEG hydrogel particles were synthesized by in situ polymerization with which the AuNPs were loaded in the PEG hydrogel particles during the polymerization. The CT intensity of the Au-PEG hydrogel particles increased, as the concentration of the loaded AuNPs and the 1st polymerization time of the polymerization process increased. In addition, when the non-ionic surfactant was used as a dispersion stabilizer, Au-PEG hydrogel particles showed good dispersibility and the highest CT density.
Keywords:polymer hydrogels;gold nanoparticles;organic/inorganic composites;in situ polymerization;computed tomography (CT) contrast agents
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