화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Korean Journal of Chemical Engineering, Vol.38, No.2, 386-399, February, 2021
DOI10.1007/s11814-020-0710-3  Export Citation
Effect of low levels of hydrotropes on micellization of phenothiazine drug
Sulaiman Y. M. Alfaifi1, Dileep Kumar2, 3, †, Malik Abdul Rub1, 4, Farah Khan5, Naved Azum1, 4, Anish Khan1, 4, Abdullah M. Asiri1, 4, and Hurija Dzudzevic-Cancar6
  • 1Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah-21589, Saudi Arabia
  • 2Division of Computational Physics, Institute for Computational Science, Ton Duc Thang University, Ho Chi Minh City, Vietnam
  • 3Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam
  • 4Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah-21589, Saudi Arabia
  • 5Department of Chemistry, Aligarh Muslim University, Aligarh-202 002, India
  • 6Department of Natural Science in Pharmacy, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71 000 Sarajevo, Bosnia and Herzegovina, Bosnia and Herzegowina
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Interactions within mixtures of the phenothiazine drug promethazine hydrochloride (PMH) and cationic hydrotropes ortho-toluidine hydrochloride (o-TDH) and para-toluidine hydrochloride (p-TDH) were investigated at different ratios and temperatures via conductometry to understand various physicochemical properties. Critical micelle concentration (cmc) was less than values of cmcid (cmc in ideal mixed system), indicating significant interaction among the studied constituents in solution mixtures. The cmc of pure PMH was also determined by measuring the surface tension for comparison. A variety of micellization thermodynamic parameters (Gibbs free energy [ΔGm 0 ], change in standard enthalpy [ΔHm 0 ], and change in entropy [ΔSm 0 ]) were computed using conductometry. The micellar mole fraction (X1 Rb, X1 Rod, and X1 id) of hydrotropes estimated by various theoretical models (Rubingh, Rodenas, and Motomura) was assessed, and the results showed a greater contribution of hydrotropes in mixed micelles along with their values increasing via an increase in mole fraction (α1) of hydrotropes (o-TDH/p-TDH). Negative β values suggest extremely favorable attractive interaction/synergism, as declines occurred in the whole quantity of amphiphile used for the desired purpose, leading to a drop of expenditure along with ecological concern. Obtained activity coefficients (f1 and f2) were always beneath unity, meaning nonideality was found between PMH and o-TDH/p-TDH. Like the conductivity method, the UV-visible and FT-IR techniques also demonstrate the interaction between the PMH and o-TDH/p-TDH.
Keywords:Promethazine Hydrochloride;Mixed Micelles;Synergism;Conductivity;Thermodynamic Parameters
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