Objective To investigate the response ofCaragana microphyllain salt condition, transcriptome analysis, differentially expressed genes (DEGs) comparison withArabidopsis thaliana, and the chlorophyll content analysis were performed. Results Gene Ontology (GO) term, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses of DEGs indicated that salt condition affected photosynthesis and chlorophyll inC. microphylla.The DEGs compared with salt responsive genes ofA. thalianaindicated thatC. microphylla'sresponses to salt differed greatly from those of the model plant and that the results also indicated up-regulated genes related to photosynthesis and chlorophyll inC. microphylla. Moreover, we confirmed that salt-treatedC. microphyllaincreased chlorophyll content, and the genes of protoporphyrin IX downstream in chlorophyll biosynthesis were induced in the heatmap analysis. Conclusions These results showed a similar pattern to some halophytes plants with increased chlorophyll at a certain salt concentration, and we assumed thatC. microphyllaalso has a mechanism to adapt or tolerate moderate salt conditions.