This study focused on the performances and kinetics of the transesterification reaction of diethyl oxalate with methanol to prepare ethyl methyl oxalate via microreactor technology. The conversion of 79.8% of diethyl oxalate (DEO) and the selectivity of 65.9% of ethyl methyl oxalate (EMO) was obtained under the following optimized conditions: the mole ratio of methanol to diethyl oxalate was 3.3:1, the temperature was 35 degrees C, the K(2)CO(3)catalyst concentration was 15 mg/mL, and the residence time was 2.30 minutes. In the temperature range of 25 degrees C to 38 degrees C, the simplified dynamic model was found to obtain the reaction order (alpha = 2.30), frequency factor (k(0)= 2.377 x 10(5)), and apparent activation energy (E = 31.86 kJ/mol). The macroscopic dynamic equation was derived from the experimental result of the transesterification reaction of two feedstocks, which can be obtained through a series of calculations.