A unique ordered mesoporous RuO2 (Meso-RuO2) catalyst with improved activity and stability is synthesized using the nano replication method. The initial activity for oxygen evolution reaction (OER) of the synthesized Meso-RuO2 catalyst is compared with that of the state-of-the-art catalyst (IrO2) and a high surface area RuO2 catalyst synthesized by the well-known Adams method (Ad-RuO2), respectively. The synthesized Meso-RuO2 catalyst exhibited lower overpotential of 266 mV at 10 mA cm(-2) than IrO2 (308 mV) or Ad-RuO2 (326 mV). Furthermore, the overpotential difference in the OER before and after the accelerated stability test for MesoRuO(2) was only 26 mV, indicating tolerable electrochemical stability. The enhanced activity and stability for the OER of the Meso-RuO2 could be attributed to the effect of the ordered mesoporous structure of RuO2 and the good electronic conductivity index (ratio of the electrochemical surface area and specific surface area). This study provides significant insights into the relationship between the OER performance and physicochemical properties of the catalysts.