The solubility of oxaprozin was determined in supercritical carbon dioxide as solvent under different temperatures and pressures using the gravimetric technique. The measured solubility data revealed that the solubility of this medication varies by changing the pressure and temperature. The oxaprozin/supercritical solvent possesses a crossover pressure at 200 bar where the influence of temperature on the solubility changes. Furthermore, the experimental data was correlated using several semi-empirical models. The best result was stated for the Kumar and Johnston model, whereas the other examined models introduced higher deviations.