Ozone (O-3) has many industrial applications such as in sterilization. One of the long-term O(3)preservation methods is molecular storage in clathrate hydrate. In this study, an experimental system was developed for continuously forming O-3 + O-2 + CO(2)hydrates. The parameters that affect the continuous operation of the system and that lead to increases in the concentration of O(3)in the hydrates were also experimentally evaluated, implementing the method of quality engineering. After optimizing these operating parameters, the O(3)storage capacity in the hydrates was measured to be 0.26 wt % at 2 h of total operation time. By X-ray diffraction, it was found that the produced sample contained hydrates, and long-term preservation for 6 months was possible at the temperature of general freezing warehouses.