Chemistry Letters, Vol.50, No.1, 180-183, 2021
Facile Synthesis of Tetraarylpyrazines by Sequential Cross-coupling Approach
A facile synthetic method for unsymmetric tetraarylpyrazines by sequential cross-couplings is disclosed. This 5-step synthesis was achieved from 2-amino-3,5-dibromo-6-chloropyrazine through four-fold cross-coupling and diazotization. Dibenzo-fused quinoxaline synthesis was also accomplished by further intramolecular coupling.