In vivo Evaluation of PEEK Copolymer Composites for Prosthetic Spine

Joon Woo Chon; Yang Xin; Seung Mook Lee; Young Jun Kim; In Sung Jeon; Jae Young Jho; Dong June Chung

Macromolecular Research, Vol.29, No.3, 244-251, March, 2021

DOI10.1007/s13233-021-9027-2 Export Citation

In vivo Evaluation of PEEK Copolymer Composites for Prosthetic Spine

Joon Woo Chon, Yang Xin¹, Seung Mook Lee¹, Young Jun Kim¹, In Sung Jeon², Jae Young Jho², and Dong June Chung^†

Department of Polymer Science & Engineering, Sungkyunkwan University Suwon, 16419, Korea
¹School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Korea
²School of Chemical and Biological Engineering, Seoul National University, Seoul, 08826, Korea

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In this study, we evaluated the biosafety of a novel polyetheretherketone (PEEK) copolymer [P(E2-E4)K] composite using an animal model to test an implanted orthopedic spine cage. The PEEK copolymer was synthesized by solution polymerization with diphenyl sulfone solvent and blended with carbon fibers and graphene oxide to produce the composite. The P(E2-E4)K composite exhibited improved mechanical properties, similar to natural bone. The animal study results for short term inflammation evaluation by hematoxylin & eosin and immunostaining methods showed significant histochemical stability for 3 weeks after implantation, demonstrating the required biosafety for medical application as an implantable spine cage.

Keywords:PEEK copolymer synthesis;PEEK composite;in vivo biosafety;spine cage application

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[Related Articles]

[1] Li Y, Wu Z, Li X, Guo Z, Wu S, Zhang Y, Shi L, Teoh S, Liu Y, Zhang Z, Biomaterials, 35, 5647 (2014)

[2] Park JB, Lakes RS, in Biomaterials: An Introduction, 3rd ed., Springer, Berlin, pp 100-136 2007.

[3] Blackwood DJ, Corros. Rev., 21, 97 (2003)

[4] Jain S, Eltorai AEM, Ruttiman R, Daniels AH, Orthop. Surg., 8, 278 (2016)

[5] Nanda A, Sharma M, Sonig A, Ambekar S, Bollam P, World Neurosurg., 82, 1380 (2014)

[6] Salahshoor M, Guo Y, Materials, 5, 135 (2012)

[7] Baidya KP, Ramakrishna S, Rahman M, Ritchie A, J. Biomater. Appl., 15, 279 (2001)

[8] Steven MK, John ND, Biomaterials, 28, 4845 (2007)

[9] Jeffey MT, Mei W, Bradley TE, Jeffrey LS, Howard BS, Turner AS, Biomaterials, 27, 324 (2006)

[10] Shariq N, Muhammad SZ, Zohaib K, Fahad S, J. Prosthodont. Res., 60, 12 (2016)

[11] Chon JW, Xin Y, Lee SM, Kim YJ, Jun IS, Jho JY, Chung DJ, Polymers, 11, 1803 (2019)

[12] ISO 10993-11, International Standard, 3rd ed., 2009.

[13] OECD Guideline for Testing of Chemical No. 406, OECD (1992).

[14] Witte F, Abeln I, Switzer E, Kaese V, Mayer-Lindenberg A, Windhagen HJ, Biomed. Mater. Res. A, 85, 1041 (2008)

[15] Arif MF, Kumar S, Varadarajan KM, Cantwell WJ, Mater. Des., 146, 249 (2018)

[16] Rivard C, Rhalmi S, Coillard C, J. Biomed. Mater. Res., 62, 488 (2002)