Moisture-induced aging and degradation are continuing concerns in long-term storage and use of silicone materials. The silica fillers frequently used to provide mechanical reinforcement in silicone formulations have a high affinity for H2O and act as a source of moisture outgassing later when placed in dry or vacuum applications. Accurate kinetic measurements and analyses are needed for reliable predictions of long-term outgassing behavior from silica-filled silicones. Here, we present a mechanistic and heuristic approach to developing a general kinetic model with a set of kinetic parameters that is appropriate for moisture outgassing from a wide range of silica-filled silicones. Data from temperature-programmed desorption and dynamic vapor sorption experiments on many different silica-filled silicones are utilized in conjunction with isoconversional and constrained iterative regression analyses to develop the general outgassing kinetic model over a wide range of temperatures. This work provides a single set of outgassing kinetic parameters to predict long-term H2O outgassing from all silica-filled silicones.