We probe, here, a family of 2D Hofmann-type frameworks, [Fe-II(Pd-(CN)(4))(bztrzX)(2)]center dot nH(2)O [X center dot nH(2)O; X = F, Cl, Br; n = 1 (X = Cl, Br) and 3 (X = F); bztrzX = (E)-1-(2-Xphen-1-yl)-N-(4H-1,2,4-triazol-4-yl)methanimine], with halogen-appended ligands. In all cases, there are two crystallographically distinct Fe-II sites, ({Fe1-Fe2}), driven by the presence of a range of host-host and host-guest interactions. We find that lattice modification through X variation influences the elastic coupling between the Fe-II sites, the emergence of ferroelastic or antiferroelastic interactions between these sites, and the relative spin-state stabilization/destabilization at each site. In Cl center dot H2O, the Fe-II sites show strong elastic coupling, as evidenced by both Fe-II sites undergoing a spin transition in a single cooperative step, as driven by the volume strain over the high-spin (HS)-to-low-spin (LS) transition. The Fe-II sites in F center dot 3H(2)O are also elastically coupled; however, the change of the X atom characteristics and increased guest molecules in the pores result in an antiferroelastic interaction characteristic between Fe1 and Fe2 and a resultant two-step spin-state transition. The change of the X atom to Br in Br center dot H2O results in the Fe-II sites being decoupled due to halogen atom steric bulk, resulting in the independent spin-state transition of Fe1 and Fe2 sites and a two-step spin-state transition pathway. Uniquely, all three possible spin-state transition pathways of a two-site switching system are observed in this family [(1) {HS-HS} <-> {HS-LS} <-> {LS-LS} for Br center dot H2O, (2) {HS-HS} <-> {LS-HS} <-> {LS-LS} for F center dot 3H(2)O, and (3) {HS-HS} <-> {LS-LS} for Cl center dot H2O for {Fe1-Fe2}]. Overall, these findings broadly support recent theoretical models but highlight that additional structural and topological complexities are needed to form a holistic picture of the drivers of elastic frustration.