Studies into the effects of parameters used in the design of proton exchange membrane (PEM) fuel cell have been done. All the modelling parameters considered influenced the performance of the PEM fuel cells. The effect of the operating condition is shown to be significant. Increasing the operating temperature and operating pressure increases the mobility of ions and as a result the ionic conductivity is increased. In addition, the membrane is dried out when the correct humidity is not provided which increases membrane degradation. Adopting good design parameter is necessary for the efficient transportation of both reactants (fuel and oxygen). With regards to the use of flow plates, the serpentine flow plate is highly recommended. Material properties are very important in material selection and new product development. For the membrane electrode area (MEA); the membrane, the ionic conductivity is very important and should be given an important consideration. This investigation thoroughly examined operating condition, design parameters and material properties necessary for PEM fuel cells experiment. The investigation will further accelerate the commercialization of fuel cells and its integration in the automotive industry.