A double chamber microbial fuel cell (MFC) reactor with anode and cathode chamber separated by a Nafion proton exchange membrane was developed and performance was evaluated for treatment of electro Fenton pretreated latex processing and production wastewater containing chemical oxygen demand of 2660 and 780 mg L-1, respectively. After 12 days, MFC treatment, the COD reduced to 133 mg/L (96%) and 86 mg/L (88.5%) for latex processing and production wastewater respectively. The MFC treatment system generated electrical energy of 1.57 and 1.04 Wh L(-1)for latex processing and production wastewaters respectively that was utilized to drive the electro-Fenton reactor. These results indicated that effective wastewater treatment, energy production, and discharge standards could be obtained in the system.