Mn12O12(O2CC6H3(NH2)(2))(16)(H2O)(4) (Mn(12)DA) is a structural mimic of the oxygen-evolving-complex in photosystem II. Herein we describe a method to integrate the Mn(12)DA with ITO electrodes using a layer-by-layer approach. Using (3-Aminopropyl)triethoxysilane, (APTES), glutaraldehyde, Mn(12)DA, and sodium cyanoborohydride as a mild reducing agent, five layers of the electrocatalysts with maximal electrocatalytic currents were obtained. The integration method limits the ligand self-oxidation and prevents the catalyst failure. Furthermore, the developed configuration enables efficient water oxidation electrocatalytic reaction at pH = 7, with an overpotential of 430 mV, a faradaic efficiency of 92% and a high turnover-number. (c) 2020 Elsevier Inc. All rights reserved.