In this study, the gravimetric method was taken to measure the solubility of the sarafloxacin hydrochloride under atmospheric pressure in methanol, isopropanol, ethanol, 1-butanol, acetonitrile, n-hexane, ethyl acetate, and N,N-dimethylformamide as well as in the (ethyl acetate + acetonitrile), (methanol + n-hexane), and (ethyl acetate + n-hexane) mixtures from 278.15 to 333.15 K. The solubility of sarafloxacin hydrochloride increased with increasing temperature in all the solvents. The solid-liquid solubility equilibrium data in the pure and mixed solvents were in apparent agreement with the solubility predicted by the modified Apelblat model, Buchowski-Ksiazaczak lambda h model, Redlich-Kister (CNIBS/R-K) model, and Jouyban-Acree model. However, the Redlich-Kister (CNIBS/R-K) model best simulated the experimental solubility results.