The high cost and relative scarcity of platinum (Pt) restrict large-scale commercialization of fuel cells, which has spurred researchers to develop low-cost alternatives integrating with high hydrogen evolution reaction (HER) and oxygen reduction reaction (ORR) catalytic activity. Herein, we performed density functional theory (DFT) calculations to explore the electrocatalytic activity of graphyne nanotubes (GyNTs). Several GyNTs were found to be potential metal-free electrocatalysts, with both HER and ORR activity superior to Pt. Moreover, we revealed a linear relationship between the Gibbs free energy change of O2 adsorption (AGOOH) and binding energy of H adsorption (AEH), which could be attributed to the fact that both the CAO bond of OOH adsorption and the CAH bond of H adsorption are single bonds. Therefore, AEH is proposed as a general descriptor for the rational design of bifunctional graphyne materials toward HERs and ORRs. Our findings provide a simple strategy for the rational design of bifunc-tional materials. (C) 2021 Elsevier Inc. All rights reserved.