Coordination polymers are highly desirable for various applications due to their functionality control of crystal structures. In this work, an unique class of amorphous Co coordination polymer spheres anchored onto 3D macroporous carbon (MPC) support (denoted as Co CPSs/MPC) was prepared via a facile hydrothermal method. The formation of Co CPSs/MPC was systematically verified by a series of characterizations, like scanning electron microscopy, Fourier transform infrared spectroscopy and X-ray diffraction, etc. The synergic effects between the superior electrical conductivity of 3D MPC supports and the excellent electrocatalytic activity of Co CPSs result in the increase of electron transfer from electrocatalyst, and then form significant number available reactive sites on the surface of electrode, which exhibit an exceptional catalytic activity and oxidation ability towards glucose. Under optimized conditions, amperometry results also indicated that the Co CPSs/MPC exhibit excellent electroanalysis towards glucose. The current work can shed light on the promising Co CPSs/MPC for further exploited as a sensitive and simple non-enzymatic glucose analytical platform. (c) 2020 Elsevier Inc. All rights reserved.