Functional metal organic framework composite can effectively remove antibiotics from environmental water samples. However, designing excellent adsorbents with multiple active sites via a rapid one-step method is still a challenging problem. A novel metal organic framework composite (UiO-66-NH2-AMPS) was synthesized through one-step polymerization by adding functional monomer 2-acryla mide-2-methylpropanesulfonic acid (AMPS) during the preparation of UiO-66-NH2. The microstructure and morphology of the UiO-66-NH2-AMPS composite were characterized, and the adsorption performance towards tylosin (TYL) in water was explored by equilibrium adsorption experiment. The results illustrated that the adsorption equilibrium can be reached within 1 h, and the maximum binding amount of UiO-66-NH2-AMPS for TYL was 161.60 mg g(-1), which was approximately 2.1-329 times of that of the other adsorbents. The pseudo second-order kinetic and Liu isotherm model were suitable for the adsorption process, and thermodynamic study displayed that the adsorption of UiO-66-NH2-AMPS composite for TYL is spontaneous and endothermal. The infrared and X-ray photoelectron spectra exhibited that hydrogen bond and electrostatic interaction were the primary recognition force for TYL. The UiO-66-NH2-AMPS composite have been successfully applied to remove TYL from environmental water. After 5 cycles, the removal efficiency of UiO-66-NH2-AMPS was still above 91.30%. (C) 2020 Elsevier Inc. All rights reserved.