This work regards the development of a distributed model predictive control strategy for large-scale systems, as centralized implementations often suffer from non-scalability. The decomposition of the overall system into minimally coupled subsystems as well as their coordination are based on optimality condition decomposition (OCD) and community detection. The OCD approach allows to solve the associated control subproblems in parallel in an iterative manner until the required degree of accuracy is attained. The proposed strategy is tested on two different systems, the quadruple-tank system and the Barcelona drinking water network, which allow to highlight the effectiveness of the approach. (C) 2021 Elsevier Ltd. All rights reserved.