The chief aim is to explore the wetting state on a microhole surface and to optimize the shape parameters of a microhole surface. A two-dimensional pseudopotential model was established, and the effects of shapes on the wetting behavior were explored. The shape parameters were optimized via the response surface methodology. The results reveal that the microhole surface can achieve a superhydrophobic state. When the diameter varies from 25 to 200 mu m, the droplet is gradually lifted. However, when the diameter of the microhole is too large, the contact angle decreases rapidly. When the microhole diameter increases, relative radii of the x- and y-directions exhibit increasing trends. With the increase of the spacing, the gaps between the microholes are gradually filled with the droplet. When spacing increases, relative radii of x- and y-directions exhibit decreasing trends. The largest contact angle of 171.246 degrees at the diameter of 76 mu m and the spacing of 48 mu m is observed.